RESEARCH FOCUS
- Processes that control the movement of the phytohormone auxin to regulate programmed and plastic plant development
- Mechanistic function of ATP Binding Cassette (ABC) transporters
- Dynamics of substrate interactions with transport proteins and their lipid environment
- Integration of light and gravity responses and modification of auxin fluxes by environemtnal stress.
- Interactions of plant defence and developmental signalling
Biography
Biography:
Research in the lab is focused on the processes that control the movement of the phytohormone auxin to regulate programmed and plastic plant development. Much of the work focuses on how those processes respond to environmental inputs and stress. Current efforts involve integration of light and gravity responses and modification of auxin fluxes by biotic and abiotic stressors. The lab also studies the transport of other aromatic acids that function in plant / fungal growth processes. We use the tools of structural biology, modeling, biochemistry, cell biology, comparative systems biology, and molecular genetics in our work.
Education:
B.A. (Honors), University of California, Santa Cruz, Biology
Ph. D, University of California, Santa Cruz
Awards and Honors:
2007-2012 Purdue University Faculty Scholar. Purdue University
2006 BBSRC Underwood Fellow. Dept Plant Sciences, University of Oxford
Professional Work
Professional Positions Held:
| 2012- 2019 | Professor and Chair, Plant Science & Landscape Architecture, University of Maryland, College Park |
| 2008-2012 | Professor, Dept. Horticulture Landscape Architecture, Purdue University |
| 2005-2008 | Assoc. Professor, Dept. Horticulture Landscape Architecture, Purdue University |
| 2003-2012 | Adjunct Professor of Biology, University of Texas Pan American |
| 2001-2005 | Asst. Professor, Dept. Horticulture Landscape Architecture, Purdue University |
| 1999-2000 | Assistant Research Biologist, University of California, Santa Cruz (UCSC) |
| 1996-1999 | Post-doctoral Fellow, UCSC |
Professional Service:
Member: AAAS, ASPB, ASHS, ASBMB, SEB, MNLGA
Editorial Board: Journal Experimental Botany, Plant and Cell Physiology, Frontiers in Plant Science
Member: Japan Prize Committee
Research
Areas of Interest:
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Auxin Transport
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ABC Transporter
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Phototropism
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Membrane nano domains
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Hormone/Herbicide Crosstalk
Current Research:
Plant hormone transport and growth
One of the longest standing projects in the lab investigates the cellular mechanisms that regulate auxin transport in dicots (Arabidopsis, tomato, cucurbits) and monocots (rice, maize, sorghum). This work has included mechanistic studies of auxin transporters and their regulation, differentiation of long distance and localized vectorial auxin transport streams, and the contributions of these streams to plant architecture and plastic responses to light and nutrients. Over the past two decades, the lab has played a major role in identifying and characterizing the auxin transport proteins from the ATP-Binding Cassette class B (ABCB) family, characterizing the subcellular mechanisms that regulate their activity, and clarifying their interactions with the PIN family of auxin transporters. More recent work has focused on light / gravity regulation of auxin transport and the impacts of salt stress on these processes. Funding for this project has come from the National Science Foundation, the Department of Energy, the US Department of Agriculture, and the Biotechnology and Biological Sciences Research Council (UK).
Structure-function analyses of ABCB transporters
b focuses on elucidation of the structural features of plant ABCB transporters that confer the relative substrate specificity as well as some conditional uptake. A major focus of this work is the generation of new ABC transporters to enhance production of engineered biofuel precursors. This work is funded by the Basic Energy Sciences Division of the U.S Department of Energy.
Herbicide uptake in plants and mammals
Movement of environmentally-applied herbicides into non target sites is a major public concern. This project in the lab was originally directed to understanding of the extent to which herbicides “drift” onto non-target crops and ornamentals, but, more recently, has also examined movement of herbicides into pets and households.
Teaching
Courses Taught:
| PLSC399: SPECIAL PROBLEMS IN PLSC | Spring 2014, Spring 2015, Spring 2016, Summer 2016 |
| PLSC400: ENVIRON PLANT PHYSIOLOGY | Spring 2013 |
| PLSC489T: SEMINAR IN PLANT SCIENCE AND LARC | Spring 2014 |
| PLSC608: RESEARCH METHODS | Fall 2013, Fall 2014, Fall 2015, Fall 2016 |
| PLSC608T: SUPERVISED TEACHING | Fall 2013, Fall 2014, Fall 2015, Fall 2016 |
| PLSC798: GRADUATE SEMINAR | Fall 2013 |
| PLSC789F: CRTQ PRMRY PLNT SCI LIT | Spring, 2014, Spring 2015 |
| PLSC789M: PLANT MEMBRANE BIOLOGY |
Spring 2013, Summer 2013, Fall 2013, Spring 2014, Summer 2014, Fall 2014, Sprign 2015, Summer 2015, Spring 2016 |
Publications
Publications
Jenness MK., Tayengwa R, Bate G A., Tapken W, Zhang Y, Pang C, Murphy AS. (2022) Loss of Multiple ABCB Auxin Transporters Recapitulates the Major twisted dwarf 1 Phenotypes in Arabidopsis thaliana. Frontiers in Plant Science.13 10.3389/fpls.2022.840260 Hammes, U. Z., Murphy, A. S., Schwechheimer, C. (2022).
Auxin Transporters-A Biochemical View. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 14(2).
Mahlandt, A., Rawat, N., Leonard, J., Venglat, P., Datla, R., Meier, N., Gill, B. S., Riera-Lizarazu, O., Coleman, G., Murphy, A. S., Tiwari, V. K. (2021). High-resolution mapping of the Mov-1 locus in wheat by combining radiation hybrid (RH) and recombination-based mapping approaches. THEORETICAL AND APPLIED GENETICS, 134(7), 2303-2314.
Li, G., Lin, R., Egekwu, C., Blakeslee, J., Lin, J., Pettengill, E., Murphy, A. S., Peer, W. A., Islam, N., Babst, B. A., Gao, F., Komarov, S., Tai, Y.-C., Coleman, G. D. (2020). Seasonal nitrogen remobilization and the role of auxin transport in poplar trees. JOURNAL OF EXPERIMENTAL BOTANY, 71(15), 4512-4530.
Jenness, M. K., Carraro, N., Pritchard, C. A., Murphy, A. S. (2020). The Arabidopsis ATP-BINDING CASSETTE Transporter ABCB21 Regulates Auxin Levels in Cotyledons, the Root Pericycle, and Leaves (vol 10, 806, 2019). FRONTIERS IN PLANT SCIENCE, 11.
Jenness, M. K., Tayengwa, R., Murphy, A. S. (2020). An ATP-Binding Cassette Transporter, ABCB19, Regulates Leaf Position and Morphology during Phototropin1-Mediated Blue Light Responses. PLANT PHYSIOLOGY, 184(3), 1601-1612.
Yang, T., Feng, H., Zhang, S., Xiao, H., Hu, Q., Chen, G., Xuan, W., Moran, N., Murphy, A., Yu, L., Xu, G. (2020). The Potassium Transporter OsHAK5 Alters Rice Architecture via ATP-Dependent Transmembrane Auxin Fluxes. Plant Communications, 1(5), 100052. http://www.sciencedirect.com/science/article/pii/S2590346220300353
Guan, L., Tayengwa, R., Cheng, Zongming (Max), Peer, W. A., Murphy, A. S., Zhao, M. (2019). Auxin regulates adventitious root formation in tomato cuttings. BMC PLANT BIOLOGY, 19(1).
Jenness, M. K., Carraro, N., Pritchard, C. A., Murphy, A. S. (2019). The Arabidopsis ATP-BINDING CASSETTE Transporter ABCB21 Regulates Auxin Levels in Cotyledons, the Root Pericycle, and Leaves. FRONTIERS IN PLANT SCIENCE, 10.
Murphy, A. (2017). Plant membranes and border control. JOURNAL OF EXPERIMENTAL BOTANY, 68(12), 3037-3040.
Dong, J., Pineros, M. A., Li, X., Yang, H., Liu, Y., Murphy, A. S., Kochian, L. V., Liu, D. (2017). An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots. MOLECULAR PLANT, 10(2), 244-259.
Li, W., Fang, C., Krishnan, S., Chen, J., Yu, H., Murphy, A. S., Merewitz, E., Katin-Grazzini, L., McAvoy, R. J., Deng, Z., Zale, J., Li, Y. (2017). Elevated auxin and reduced cytokinin contents in rootstocks improve their performance and grafting success. PLANT BIOTECHNOLOGY JOURNAL, 15(12), 1556-1565.
Lin, C.-Y., Jakes, J. E., Donohoe, B. S., Ciesielski, P. N., Yang, H., Gleber, S.-C., Vogt, S., Ding, S.-Y., Peer, W. A., Murphy, A. S., McCann, M. C., Himmel, M. E., Tucker, M. P., Wei, H. (2016). Directed plant cell-wall accumulation of iron: embedding co-catalyst for efficient biomass conversion. BIOTECHNOLOGY FOR BIOFUELS, 9.
Yang, H., Wei, H., Ma, G., Antunes, M. S., Vogt, S., Cox, J., Zhang, X., Liu, X., Bu, L., Gleber, S. C., Carpita, N. C., Makowski, L., Himmel, M. E., Tucker, M. P., McCann, M. C., Murphy, A. S., Peer, W. A. (2016). Cell wall targeted in planta iron accumulation enhances biomass conversion and seed iron concentration in Arabidopsis and rice. PLANT BIOTECHNOLOGY JOURNAL, 14(10), 1998-2009.
Blakeslee, J. J., Murphy, A. S. (2016). Microscopic and Biochemical Visualization of Auxins in Plant Tissues. ENVIRONMENTAL RESPONSES IN PLANTS: METHODS AND PROTOCOLS, 1398, 37-53.
Siligato, R., Wang, X., Yadav, S. R., Lehesranta, S., Ma, G., Ursache, R., Sevilem, I., Zhang, J., Gorte, M., Prasad, K., Wrzaczek, M., Heidstra, R., Murphy, A., Scheres, B., Maehoenen, A. P. (2016). MultiSite Gateway-Compatible Cell Type-Specific Gene-Inducible System for Plants. PLANT PHYSIOLOGY, 170(2), 627-641.
Kriegel, A., Andres, Z., Medzihradszky, A., Krueger, F., Scholl, S., Delang, S., Goerkem Patir-Nebioglu, M., Gute, G., Yang, H., Murphy, A. S., Peer, W. A., Pfeiffer, A., Krebs, M., Lohmann, J. U., Schumacher, K. (2015). Job Sharing in the Endomembrane System: Vacuolar Acidification Requires the Combined Activity of V-ATPase and V-PPase. PLANT CELL, 27(12), 3383-3396.
Wei, H., Yang, H., Ciesielski, P. N., Donohoe, B. S., McCann, M. C., Murphy, A. S., Peer, W. A., Ding, S.-Y., Himmel, M. E., Tucker, M. P. (2015). Transgenic ferritin overproduction enhances thermochemical pretreatments in Arabidopsis. BIOMASS & BIOENERGY, 72, 55-64.
Guan, L., Murphy, A. S., Peer, W. A., Gan, L., Li, Y., Cheng, Zong-Ming (Max) (2015). Physiological and Molecular Regulation of Adventitious Root Formation. CRITICAL REVIEWS IN PLANT SCIENCES, 34(5), 506-521.
Simaskova, M., O'Brien, J. A., Khan, M., Van Noorden, Giel, Oetvoes, K., Vieten, A., De Clercq, Inge, Van Haperen, Johanna Maria Adriana, Cuesta, C., Hoyerova, K., Vanneste, S., Marhavy, P., Wabnik, K., Van Breusegem, Frank, Nowack, M., Murphy, A., Friml, J., Weijers, D., Beeckman, T., Benkova, E. (2015). Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATIONS, 6.
McCann, M., Abu-Omar, M., Agrawal, R., Bozell, J., Carpita, N., Chapple, C., Crowley, M., Delgass, N., Donohoe, B., Himmel, M., Kenttamaa, H., Makowski, L., Meilan, R., Mosier, N., Murphy, A., Peer, W., Ribeiro, F., Tucker, M. (2015). Tailoring Biomass for Biochemical, Chemical or Thermochemical Catalytic Conversion. FASEB JOURNAL, 29.
Voss, U., Wilson, M. H., Kenobi, K., Gould, P. D., Robertson, F. C., Peer, W. A., Lucas, M., Swarup, K., Casimiro, I., Holman, T. J., Wells, D. M., Peret, B., Goh, T., Fukaki, H., Hodgman, T. C., Laplaze, L., Halliday, K. J., Ljung, K., Murphy, A. S., Hall, A. J., Webb, Alex A. R., Bennett, M. J. (2015). The circadian clock rephases during lateral root organ initiation in Arabidopsis thaliana. NATURE COMMUNICATIONS, 6.
Tapken, W., Murphy, A. S. (2015). Membrane nanodomains in plants: capturing form, function, and movement. JOURNAL OF EXPERIMENTAL BOTANY, 66(6), 1573-1586.
Spartz, A. K., Ren, H., Park, M. Y., Grandt, K. N., Lee, S. H., Murphy, A. S., Sussman, M. R., Overvoorde, P. J., Gray, W. M. (2014). SAUR Inhibition of PP2C-D Phosphatases Activates Plasma Membrane H+-ATPases to Promote Cell Expansion in Arabidopsis. PLANT CELL, 26(5), 2129-2142.
Yang, H., Zhang, X., Gaxiola, R. A., Xu, G., Peer, W. A., Murphy, A. S. (2014). Over-expression of the Arabidopsis proton-pyrophosphatase AVP1 enhances transplant survival, root mass, and fruit development under limiting phosphorus conditions. JOURNAL OF EXPERIMENTAL BOTANY, 65(12), 3045-3053.
Sze, H., Geisler, M., Murphy, A. S. (2014). Linking the evolution of plant transporters to their functions. FRONTIERS IN PLANT SCIENCE, 4.
Hayashi, K.-I., Nakamura, S., Fukunaga, S., Nishimura, T., Jenness, M. K., Murphy, A. S., Motose, H., Nozaki, H., Furutani, M., Aoyama, T. (2014). Auxin transport sites are visualized in planta using fluorescent auxin analogs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(31), 11557-11562.
Marhavy, P., Duclercq, J., Weller, B., Feraru, E., Bielach, A., Offringa, R., Friml, J., Schwechheimer, C., Murphy, A., Benkova, E. (2014). Cytokinin Controls Polarity of PIN1-Dependent Auxin Transport during Lateral Root Organogenesis. CURRENT BIOLOGY, 24(9), 1031-1037.
Li, R., Li, J., Li, S., Qin, G., Novak, O., Pencik, A., Ljung, K., Aoyama, T., Liu, J., Murphy, A., Gu, H., Tsuge, T., Qu, L.-J. (2014). ADP1 Affects Plant Architecture by Regulating Local Auxin Biosynthesis. PLOS GENETICS, 10(1).
Peer, W. A., Jenness, M. K., Murphy, A. S. (2014). Measure for measure: determining, inferring and guessing auxin gradients at the root tip. PHYSIOLOGIA PLANTARUM, 151(1), 97-111.
Garay-Arroyo, A., Ortiz-Moreno, E., de la Paz Sanchez, Maria, Murphy, A. S., Garcia-Ponce, B., Marsch-Martinez, N., de Folter, Stefan, Corvera-Poire, A., Jaimes-Miranda, F., Pacheco-Escobedo, M. A., Dubrovsky, J. G., Pelaz, S., Alvarez-Buylla, E. R. (2013). The MADS transcription factor XAL2/AGL14 modulates auxin transport during Arabidopsis root development by regulating PIN expression. EMBO JOURNAL, 32(21), 2884-2895.
Knapp, D. W., Peer, W. A., Conteh, A., Diggs, A. R., Cooper, B. R., Glickman, N. W., Bonney, P. L., Stewart, J. C., Glickman, L. T., Murphy, A. S. (2013). Detection of herbicides in the urine of pet dogs following home lawn chemical application. SCIENCE OF THE TOTAL ENVIRONMENT, 456, 34-41.
Drdova, E. J., Synek, L., Pecenkova, T., Hala, M., Kulich, I., Fowler, J. E., Murphy, A. S., Zarsky, V. (2013). The exocyst complex contributes to PIN auxin efflux carrier recycling and polar auxin transport in Arabidopsis. PLANT JOURNAL, 73(5), 709-719.
Yang, H., Richter, G. L., Wang, X., Mlodzinska, E., Carraro, N., Ma, G., Jenness, M., Chao, D.-y., Peer, W. A., Murphy, A. S. (2013). Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter. PLANT JOURNAL, 74(1), 37-47.
Yu, H., Karampelias, M., Robert, S., Peer, W. A., Swarup, R., Ye, S., Ge, L., Cohen, J., Murphy, A., Friml, J., Estelle, M. (2013). ROOT ULTRAVIOLET B-SENSITIVE1/WEAK AUXIN RESPONSE3 Is Essential for Polar Auxin Transport in Arabidopsis. PLANT PHYSIOLOGY, 162(2), 965-976.
Christie, J. M., Murphy, A. S. (2013). SHOOT PHOTOTROPISM IN HIGHER PLANTS: NEW LIGHT THROUGH OLD CONCEPTS. AMERICAN JOURNAL OF BOTANY, 100(1), 35-46.
Geisler, M., Murphy, A. S., Sze, H. (2013). Evolution of Membrane Signaling and Trafficking in Plants. Frontiers Media SA. Dept Plant Science and Landscape Architecture, 2104 Plant Sciences Bldg
Peer, W. A., Cheng, Y., Murphy, A. S. (2013). Evidence of oxidative attenuation of auxin signalling. JOURNAL OF EXPERIMENTAL BOTANY, 64(9), 2629-2639.
Spartz, A. K., Lee, S. H., Wenger, J. P., Gonzalez, N., Itoh, H., Inze, D., Peer, W. A., Murphy, A. S., Overvoorde, P. J., Gray, W. M. (2012). The SAUR19 subfamily of SMALL AUXIN UP RNA genes promote cell expansion. PLANT JOURNAL, 70(6), 978-990.
Murphy, A. S., Peer, W. A. (2012). Vesicle Trafficking: ROP-RIC Roundabout. CURRENT BIOLOGY, 22(14), R576-R578.
Bailly, A., Yang, H., Martinoia, E., Geisler, M., Murphy, A. S. (2012). Plant lessons: exploring ABCB functionality through structural modeling. FRONTIERS IN PLANT SCIENCE, 2.
Peret, B., Swarup, K., Ferguson, A., Seth, M., Yang, Y., Dhondt, S., James, N., Casimiro, I., Perry, P., Syed, A., Yang, H., Reemmer, J., Venison, E., Howells, C., Perez-Amador, M. A., Yun, J., Alonso, J., Beemster, Gerrit T. S., Laplaze, L., Murphy, A., Bennett, M. J., Nielsen, E., Swarup, R. (2012). AUX/LAX Genes Encode a Family of Auxin Influx Transporters That Perform Distinct Functions during Arabidopsis Development. PLANT CELL, 24(7), 2874-2885.
Dweikat, I., Weil, C., Moose, S., Kochian, L., Mosier, N., Ileleji, K., Brown, P., Peer, W., Murphy, A., Taheripour, F., McCann, M., Carpita, N. (2012). Envisioning the transition to a next-generation biofuels industry in the US Midwest. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, 6(4), 376-386.
Kubes, M., Yang, H., Richter, G. L., Cheng, Y., Mlodzinska, E., Wang, X., Blakeslee, J. J., Carraro, N., Petrasek, J., Zazimalova, E., Hoyerova, K., Peer, W. A., Murphy, A. S. (2012). The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis. PLANT JOURNAL, 69(4), 640-654.
Ding, Z., Wang, B., Moreno, I., Duplakova, N., Simon, S., Carraro, N., Reemmer, J., Pencik, A., Chen, X., Tejos, R., Skupa, P., Pollmann, S., Mravec, J., Petrasek, J., Zazimalova, E., Honys, D., Rolcik, J., Murphy, A., Orellana, A., Geisler, M., Friml, J. (2012). ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. NATURE COMMUNICATIONS, 3.
Murphy, A. S. (2011). Grand challenge: viewing transporter function in a pointillist landscape. FRONTIERS IN PLANT SCIENCE, 2.
Knoeller, A. S., Murphy, A. S. (2011). ABC Transporters and Their Function at the Plasma Membrane. PLANT PLASMA MEMBRANE, 19, 353-377.
Tsuda, E., Yang, H., Nishimura, T., Uehara, Y., Sakai, T., Furutani, M., Koshiba, T., Hirose, M., Nozaki, H., Murphy, A. S., Hayashi, K.-i. (2011). Alkoxy-auxins Are Selective Inhibitors of Auxin Transport Mediated by PIN, ABCB, and AUX1 Transporters. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(3), 2354-2364.
Monshausen, G. B., Miller, N. D., Murphy, A. S., Gilroy, S. (2011). Dynamics of auxin-dependent Ca2+ and pH signaling in root growth revealed by integrating high-resolution imaging with automated computer vision-based analysis. PLANT JOURNAL, 65(2), 309-318.
Kim, J. I., Murphy, A. S., Baek, D., Lee, S.-W., Yun, D.-J., Bressan, R. A., Narasimhan, M. L. (2011). YUCCA6 over-expression demonstrates auxin function in delaying leaf senescence in Arabidopsis thaliana. JOURNAL OF EXPERIMENTAL BOTANY, 62(11), 3981-3992.
Christie, J. M., Yang, H., Richter, G. L., Sullivan, S., Thomson, C. E., Lin, J., Titapiwatanakun, B., Ennis, M., Kaiserli, E., Lee, O. R., Adamec, J., Peer, W. A., Murphy, A. S. (2011). phot1 Inhibition of ABCB19 Primes Lateral Auxin Fluxes in the Shoot Apex Required For Phototropism. PLOS BIOLOGY, 9(6).
Dubrovsky, J. G., Napsucialy-Mendivil, S., Duclercq, J., Cheng, Y., Shishkova, S., Ivanchenko, M. G., Friml, J., Murphy, A. S., Benkova, E. (2011). Auxin minimum defines a developmental window for lateral root initiation. NEW PHYTOLOGIST, 191(4), 970-983.
Hildreth, S. B., Gehman, E. A., Yang, H., Lu, R.-H., Ritesh, K. C., Harich, K. C., Yu, S., Lin, J., Sandoe, J. L., Okumoto, S., Murphy, A. S., Jelesko, J. G. (2011). Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(44), 18179-18184.
Peer, W. A., Blakeslee, J. J., Yang, H., Murphy, A. S. (2011). Seven Things We Think We Know about Auxin Transport. MOLECULAR PLANT, 4(3), 487-504.
Qi, Y., Tsuda, K., Nguyen, Le V., Wang, X., Lin, J., Murphy, A. S., Glazebrook, J., Thordal-Christensen, H., Katagiri, F. (2011). Physical Association of Arabidopsis Hypersensitive Induced Reaction Proteins (HIRs) with the Immune Receptor RPS2. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(36), 31297-31307.
Knoeller, A. S., Blakeslee, J. J., Richards, E. L., Peer, W. A., Murphy, A. S. (2010). Brachytic2/ZmABCB1 functions in IAA export from intercalary meristems. JOURNAL OF EXPERIMENTAL BOTANY, 61(13), 3689-3696.
McLamore, E. S., Diggs, A., Marzal, P. C., Shi, J., Blakeslee, J. J., Peer, W. A., Murphy, A. S., Porterfield, D. M. (2010). Non-invasive quantification of endogenous root auxin transport using an integrated flux microsensor technique. PLANT JOURNAL, 63(6), 1004-1016.
Zazimalova, E., Murphy, A. S., Yang, H., Hoyerova, K., Hosek, P. (2010). Auxin Transporters - Why So Many? COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2(3).
Hosein, F. N., Bandyopadhyay, A., Peer, W. A., Murphy, A. S. (2010). The Catalytic and Protein-Protein Interaction Domains Are Required for APM1 Function. PLANT PHYSIOLOGY, 152(4), 2158-2172.
Ruzicka, K., Strader, L. C., Bailly, A., Yang, H., Blakeslee, J., Langowski, L., Nejedla, E., Fujita, H., Itoh, H., Syono, K., Hejatko, J., Gray, W. M., Martinoia, E., Geisler, M., Bartel, B., Murphy, A. S., Friml, J. (2010). Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(23), 10749-10753.
Titapiwatanakun, B., Murphy, A. S. (2009). Post-transcriptional regulation of auxin transport proteins: cellular trafficking, protein phosphorylation, protein maturation, ubiquitination, and membrane composition. JOURNAL OF EXPERIMENTAL BOTANY, 60(4), 1093-1107.
Titapiwatanakun, B., Blakeslee, J. J., Bandyopadhyay, A., Yang, H., Mravec, J., Sauer, M., Cheng, Y., Adamec, J., Nagashima, A., Geisler, M., Sakai, T., Friml, J., Peer, W. A., Murphy, A. S. (2009). ABCB19/PGP19 stabilises PIN1 in membrane microdomains in Arabidopsis. PLANT JOURNAL, 57(1), 27-44.
Yang, H., Murphy, A. S. (2009). Functional expression and characterization of Arabidopsis ABCB, AUX 1 and PIN auxin transporters in Schizosaccharomyces pombe. PLANT JOURNAL, 59(1), 179-191.
Li, H., Cheng, Y., Murphy, A., Hagen, G., Guilfoyle, T. J. (2009). Constitutive Repression and Activation of Auxin Signaling in Arabidopsis. PLANT PHYSIOLOGY, 149(3), 1277-1288.
Moore, I., Murphy, A. (2009). Validating the Location of Fluorescent Protein Fusions in the Endomembrane System. PLANT CELL, 21(6), 1632-1636.
Peer, W. A., Hosein, F. N., Bandyopadhyay, A., Makam, S. N., Otegui, M. S., Lee, G.-J., Blakeslee, J. J., Cheng, Y., Titapiwatanakun, B., Yakubov, B., Bangari, B., Murphy, A. S. (2009). Mutation of the Membrane-Associated M1 Protease APM1 Results in Distinct Embryonic and Seedling Developmental Defects in Arabidopsis. PLANT CELL, 21(6), 1693-1721.
Frommer, W. B., Schulz, B., Murphy, A. S. (2009). Evaluating the function of putative hormone transporters. Plant Signaling & Behavior, 4(2), 147-148. http://dx.doi.org/10.4161/psb.4.2.7681
Rojas-Pierce, M., Titapiwatanakun, B., Sohn, E. J., Fang, F., Larive, C. K., Blakeslee, J., Cheng, Y., Cuttler, S., Peer, W. A., Murphy, A. S., Raikhel, N. V. (2008). Arabidopsis P-glycoprotein19 participates in the inhibition of Gravitropism by gravacin (vol 14, pg 1366, 2008). CHEMISTRY & BIOLOGY, 15(1), 87-87.
Verrier, P. J., Bird, D., Buria, B., Dassa, E., Forestier, C., Geisler, M., Klein, M., Kolukisaoglu, U., Lee, Y., Martinoia, E., Murphy, A., Rea, P. A., Samuels, L., Schulz, B., Spalding, E. P., Yazaki, K., Theodoulou, F. L. (2008). Plant ABC proteins - a unified nomenclature and updated inventory. TRENDS IN PLANT SCIENCE, 13(4), 151-159.
Jain, A., Poling, M. D., Karthikeyan, A. S., Blakeslee, J. J., Peer, W. A., Titapiwatanakun, B., Murphy, A. S., Raghothama, K. G. (2007). Differential effects of sucrose and auxin on localized phosphate deficiency-induced modulation of different traits of root system architecture in Arabidopsis. PLANT PHYSIOLOGY, 144(1), 232-247.
Alpi, A., Amrhein, N., Bertl, A., Blatt, M. R., Blumwald, E., Cervone, F., Dainty, J., De Michelis, Maria Ida, Epstein, E., Galston, A. W., Goldsmith, Mary Helen M., Hawes, C., Hell, R., Hetherington, A., Hofte, H., Juergens, G., Leaver, C. J., Moroni, A., Murphy, A., Oparka, K., Perata, P., Quader, H., Rausch, T., Ritzenthaler, C., Rivetta, A., Robinson, D. G., Sanders, D., Scheres, B., Schumacher, K., Sentenac, H., Slayman, C. L., Soave, C., Somerville, C., Taiz, L., Thiel, G., Wagner, R. (2007). Plant neurobiology: no brain, no gain? TRENDS IN PLANT SCIENCE, 12(4), 135-136.
Yang, H., Knapp, J., Koirala, P., Rajagopal, D., Peer, W. A., Silbart, L. K., Murphy, A., Gaxiola, R. A. (2007). Enhanced phosphorus nutrition in monocots and dicots over-expressing a phosphorus-responsive type IH+-pyrophosphatase. PLANT BIOTECHNOLOGY JOURNAL, 5(6), 735-745.
Kim, J. I., Sharkhuu, A., Jin, J. B., Li, P., Jeong, J. C., Baek, D., Lee, S. Y., Blakeslee, J. J., Murphy, A. S., Bohnert, H. J., Hasegawa, P. M., Yun, D.-J., Bressan, R. A. (2007). yucca6, a dominant mutation in arabidopsis, affects auxin accumulation and auxin-related phenotypes. PLANT PHYSIOLOGY, 145(3), 722-735.
Blakeslee, J. J., Bandyopadhyay, A., Lee, O. R., Mravec, J., Titapiwatanakun, B., Sauer, M., Makam, S. N., Cheng, Y., Bouchard, R., Adamec, J., Geisler, M., Nagashima, A., Sakai, T., Martinoia, E., Friml, J., Peer, W. A., Murphy, A. S. (2007). Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis. PLANT CELL, 19(1), 131-147.
Rojas-Pierce, M., Titapiwatanakun, B., Sohn, E. J., Fang, F., Larive, C. K., Blakeslee, J., Cheng, Y., Cuttler, S., Peer, W. A., Murphy, A. S., Raikhel, N. V. (2007). Arabidopsis P-glycoprotein19 participates in the inhibition of Gravitropism by gravacin. CHEMISTRY & BIOLOGY, 14(12), 1366-1376.
Green, R. J., Murphy, A. S., Schulz, B., Watkins, B. A., Ferruzzi, M. G. (2007). Common tea formulations modulate in vitro digestive recovery of green tea catechins. MOLECULAR NUTRITION & FOOD RESEARCH, 51(9), 1152-1162.
Shin, R., Burch, A. Y., Huppert, K. A., Tiwari, S. B., Murphy, A. S., Guilfoyle, T. J., Schachtman, D. P. (2007). The Arabidopsis transcription factor MYB77 modulates auxin signal transduction. PLANT CELL, 19(8), 2440-2453.
Peer, W. A., Murphy, A. S. (2007). Flavonoids and auxin transport: modulators or regulators? TRENDS IN PLANT SCIENCE, 12(12), 556-563.
Bandyopadhyay, A., Blakeslee, J. J., Lee, O. R., Mravec, J., Sauer, M., Titapiwatanakun, B., Makam, S. N., Bouchard, R., Geisler, M., Martinoia, E., Friml, J., Peer, W. A., Murphy, A. S. (2007). Interactions of PIN and PGP auxin transport mechanisms. Biochemical Society transactions, 35(Pt 1), 137-41.
Orlova, I., Marshall-Colon, A., Schnepp, J., Wood, B., Varbanova, M., Fridman, E., Blakeslee, J. J., Peer, W. A., Murphy, A. S., Rhodes, D., Pichersky, E., Dudareva, N. (2006). Reduction of benzenoid synthesis in petunia flowers reveals multiple pathways to benzoic acid and enhancement in auxin transport. PLANT CELL, 18(12), 3458-3475.
Petrasek, J., Mravec, J., Bouchard, R., Blakeslee, J., Abas, M., Seifertova, D., Wisniewska, J., Tadele, Z., Kubes, M., Covanova, M., Dhonukshe, P., Skupa, P., Benkova, E., Perry, L., Krecek, P., Lee, O., Fink, G., Geisler, M., Murphy, A., Luschnig, C., Zazimalova, E., Friml, J. (2006). PIN proteins perform a rate-limiting function in cellular auxin efflux. SCIENCE, 312(5775), 914-918.
Geisler, M., Murphy, A. (2006). The ABC of auxin transport: The role of p-glycoproteins in plant development. FEBS LETTERS, 580(4), 1094-1102.
Bouchard, R., Bailly, A., Blakeslee, J. J., Oehring, S. C., Vincenzetti, V., Lee, O. R., Paponov, I., Palme, K., Mancuso, S., Murphy, A. S., Schulz, B., Geisler, M. (2006). Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(41), 30603-30612.
Peer, W. A., Mahmoudian, M., Freeman, J. L., Lahner, B., Richards, E. L., Reeves, R. D., Murphy, A. S., Salt, D. E. (2006). Assessment of plants from the Brassicaceae family as genetic models for the study of nickel and zinc hyperaccumulation. NEW PHYTOLOGIST, 172(2), 248-260.
Murphy, A., Bandyopadhyay, A., Holstein, S., Peer, W. (2005). Endocytotic cycling of PM proteins. ANNUAL REVIEW OF PLANT BIOLOGY, 56, 221-251.
Baxter, I., Young, J., Armstrong, G., Foster, N., Bogenschutz, N., Cordova, T., Peer, W., Hazen, S., Murphy, A., Harper, J. (2005). A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(7), 2649-2654.
Blakeslee, J., Peer, W., Murphy, A. (2005). Auxin transport. CURRENT OPINION IN PLANT BIOLOGY, 8(5), 494-500.
Li, J., Yang, H., Peer, W., Richter, G., Blakeslee, J., Bandyopadhyay, A., Titapiwantakun, B., Undurraga, S., Khodakovskaya, M., Richards, E., Krizek, B., Murphy, A., Gilroy, S., Gaxiola, R. (2005). Arabidopsis H+-PPase AVP1 regulates auxin-mediated organ development. SCIENCE, 310(5745), 121-125.
Terasaka, K., Blakeslee, J., Titapiwatanakun, B., Peer, W., Bandyopadhyay, A., Makam, S., Lee, O., Richards, E., Murphy, A., Sato, F., Yazaki, K. (2005). PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots. PLANT CELL, 17(11), 2922-2939.
Geisler, M., Blakeslee, J., Bouchard, R., Lee, O., Vincenzetti, V., Bandyopadhyay, A., Titapiwatanakun, B., Peer, W., Bailly, A., Richards, E., Ejenda, K., Smith, A., Baroux, C., Grossniklaus, U., Muller, A., Hrycyna, C., Dudler, R., Murphy, A., Martinoia, E. (2005). Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. PLANT JOURNAL, 44(2), 179-194.
Makam, S., Peer, W., Blakeslee, J., Murphy, A. (2005). Cultural conditions contributing to vine decline syndrome in watermelon. HORTSCIENCE, 40(3), 597-601.
Blakeslee, J., Bandyopadhyay, A., Peer, W., Makam, S., Murphy, A. (2004). Relocalization of the PIN1 auxin efflux facilitator plays a role in phototropic responses. PLANT PHYSIOLOGY, 134(1), 28-31.
Peer, W., Bandyopadhyay, A., Blakeslee, J., Makam, S., Chen, R., Masson, P., Murphy, A. (2004). Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana. PLANT CELL, 16(7), 1898-1911.
Smith, A., Nourizadeh, S., Peer, W., Xu, J., Bandyopadhyay, A., Murphy, A., Goldsbrough, P. (2003). Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids. PLANT JOURNAL, 36(4), 433-442.
Noh, B., Bandyopadhyay, A., Peer, W., Spalding, E., Murphy, A. (2003). Enhanced gravi- and phototropism in plant mdr mutants mislocalizing the auxin efflux protein PIN1. NATURE, 423(6943), 999-1002.
Muday, G., Peer, W., Murphy, A. (2003). Vesicular cycling mechanisms that control auxin transport polarity. TRENDS IN PLANT SCIENCE, 8(7), 301-304.
Geisler, M., Kolukisaoglu, H., Bouchard, R., Billion, K., Berger, J., Saal, B., Frangne, N., Koncz-Kalman, Z., Koncz, C., Dudler, R., Blakeslee, J., Murphy, A., Martinoia, E., Schulz, B. (2003). TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. MOLECULAR BIOLOGY OF THE CELL, 14(10), 4238-4249.
Peer, W., Murphy, A. (2003). Floral scent of Arabidopsis lyrata (Brassicaceae). BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 31(10), 1193-1195.
Peer, W., Mamoudian, M., Lahner, B., Reeves, R., Murphy, A., Salt, D. (2003). Identifying model metal hyperaccumulating plants: germplasm analysis of 20 Brassicaceae accessions from a wide geographical area. NEW PHYTOLOGIST, 159(2), 421-430.
Murphy, A., Hoogner, K., Peer, W., Taiz, L. (2002). Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis. PLANT PHYSIOLOGY, 128(3), 935-950.
Muday, G., Murphy, A. (2002). An emerging model of auxin transport regulation. PLANT CELL, 14(2), 293-299.
Noh, B., Murphy, A., Spalding, E. (2001). Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. PLANT CELL, 13(11), 2441-2454.
Brown, D., Rashotte, A., Murphy, A., Normanly, J., Tague, B., Peer, W., Taiz, L., Muday, G. (2001). Flavonoids act as negative regulators of auxin transport in vivo in Arabidopsis. PLANT PHYSIOLOGY, 126(2), 524-535.
Peer, W., Brown, D., Tague, B., Muday, G., Taiz, L., Murphy, A. (2001). Flavonoid accumulation patterns of transparent testa mutants of Arabidopsis. PLANT PHYSIOLOGY, 126(2), 536-548.
Murphy, A., Taiz, L. (1999). Localization and characterization of soluble and plasma membrane aminopeptidase activities in Arabidopsis seedlings. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 37(6), 431-443.
Murphy, A., Taiz, L. (1999). Naphthylphthalamic acid is enzymatically hydrolyzed at the hypocotyl-root transition zone and other tissues of Arabidopsis thaliana seedlings. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 37(6), 413-430.
Murphy, A., Eisinger, W., Shaff, J., Kochian, L., Taiz, L. (1999). Early copper-induced leakage of K+ from Arabidopsis seedlings is mediated by ion channels and coupled to citrate efflux. PLANT PHYSIOLOGY, 121(4), 1375-1382.
Garcia-Hernandez, M., Murphy, A., Taiz, L. (1998). Metallothioneins 1 and 2 have distinct but overlapping expression patterns in Arabidopsis. PLANT PHYSIOLOGY, 118(2), 387-397.
Murphy, A., Zhou, J., Goldsbrough, P., Taiz, L. (1997). Purification and immunological identification of metallothioneins 1 and 2 from Arabidopsis thaliana. PLANT PHYSIOLOGY, 113(4), 1293-1301.
MURPHY, A., TAIZ, L. (1995). A NEW VERTICAL MESH TRANSFER TECHNIQUE FOR METAL-TOLERANCE STUDIES IN ARABIDOPSIS - ECOTYPIC VARIATION AND COPPER-SENSITIVE MUTANTS. PLANT PHYSIOLOGY, 108(1), 29-38.
MURPHY, A., TAIZ, L. (1995). COMPARISON OF METALLOTHIONEIN GENE-EXPRESSION AND NONPROTEIN THIOLS IN 10 ARABIDOPSIS ECOTYPES - CORRELATION WITH COPPER TOLERANCE. PLANT PHYSIOLOGY, 109(3), 945-954.
Taiz, L., Alkon, D., Draguhn, A., Murphy, A., Blatt, M., Thiel, G., Robinson, D. G. (2020). Reply to Trewavas et al. and Calvo and Trewavas (3rd ed., vol. 25, pp. 218-220).
Vincelli, P., Jackson-Smith, D., Holsapple, M., Grusak, M. A., Harsh, M., Klein, T., Lambert, J., Lange, B. M., Lodge, D. M., McCluskey, J., Murphy, A., Neuhouser, M. L., Pray, C., Weller, S. (2017). National Academies report has broad support (4th ed., vol. 35, pp. 304-306).
Murphy, A. (2015). Hormone crosstalk in plants Preface (16th ed., vol. 66, pp. 4853-4854).
Baskin, T. I., Peret, B., Baluska, F., Benfey, P. N., Bennett, M., Forde, B. G., Gilroy, S., Helariutta, Y., Hepler, P. K., Leyser, O., Masson, P. H., Muday, G. K., Murphy, A. S., Poethig, S., Rahman, A., Roberts, K., Scheres, B., Sharp, R. E., Somerville, C. (2010). Shootward and rootward: peak terminology for plant polarity (11th ed., vol. 15, pp. 593-594).
II.C.4. Other
II.D. Published Conference Proceedings
Books
1. Evolution of Membrane Signaling and Trafficking in Plants (2013) Geisler M, Murphy AS, Sze Frontiers Media SA, Geneva, ISBN: 978-2-88919-131-4
2. The Plant Plasma Membrane (2010)Murphy AS, Peer WA, Schulz B, Eds. Springer Verlag, Heidelberg.
3. Plant Physiology and Development (6th edition 2014) co-author with Lincoln Taiz, Eduardo Zeiger, Max Moeller, Sinauer Press, Sunderland, MA.
Book chapters
1. Jenness M and Murphy AS (2014) Evolution of Transport Directionality in ABCBs. In Plant ABC Transporters Markus Geisler, Ed. Springer, Berlin.
2. Knöller AS, Murphy AS (2010) ABC transporters and their function at the plasma membrane The Plant Plasma Membrane, Plant Cell Monographs, Springer, Berlin.
2. Murphy AS (2010) Auxin: the first growth hormone. In Plant Physiology, 5th Edition, L Taiz and E Zeiger, eds, Sinauer Associates, Sunderland MA.
3. Peer WA, Murphy AS (2008) Flavonoid signaling: targets of flavonoid action. In The Science of Flavonoids, 2nd edition, Erich Grotewald Ed, Springer Verlag, New York.
4. Murphy AS (2006) Auxin: the Growth Hormone. In Plant Physiology, fourth edition, Taiz L, Zeiger E, Eds. Sinauer Associates, Sunderland MA.
5. Peer WA, Baxter IR, Richards EL, Freeman JL, Murphy AS (2005) Phytoremediation and Hyperaccumulator Plants. In Molecular Biology of Metal Homeostasis and Detoxification; from microbes to man’ in the book series Topics in Current Genetics, LWJ Klomp, E Martinoia, MJ Tamás, eds. Springer. Berlin 2006.
6. Peer WA, Murphy AS (2005) Flavonoid signaling. In The Science of Flavonoids, Erich Grotewald Ed, Springer Verlag New York.
7. Blakeslee JJ, Peer WA, Murphy AS (2005) Endocytotic cycling of MDR/PGPs. Plant Endocytosis, Frantisek Baluska and Jozef Samaj, Eds. Elsevier, Berlin 159-176.
8. Murphy AS (2002) Auxin: the Growth Hormone. In Plant Physiology, Taiz L, Zeiger E, eds. Sinauer Associates, Sunderland MA.
